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To evaluate the early background of serum HCG β-subunit in pregnancy, 12 pregnancies achived by ovulation induction were studied, which included 8 siglton pregnancies, 1 twin pregnancy, 2 clinical abortions, 1 ectopic pregnancy. We measured the serial serum concentrations of HCG β-subunit on -1,0,7,12,16,18th days after ovulation. The results were as follows; 1. No significant increasement of β-HCG in all cases was found on preovulatory and ovulatory day when 5000 IU HCG was injected on preovulatory and ovulatory day, serum β-HCG decreased to less than 5mIU/ml within 7days in 83% of the cases. 3. β-HCG values on the 12th day after ovulation were 49mIU/ml highest in twin pregnancy, 19.63±9.73mIU/ml and 18.00±8.00mIU/ml simularly in normal signleton pregnancy and spontaneous abortion respectively and 4mIU/ml lowest in ectopic pregnancy. 4. β-HCG values on the 14th day after ovulation were 169mIU/ml highest in twin pregnancy, 69.25±37.12 mIU/ml and 67.00±17.00mIU/ml similary in normal sigleton pregnancy and spontaneous abortion respecively and 11mIU/ml lowest in ectopic pregnancy. 5. β-HCG values on 16th day after ovulation were 652 mIU/ml highest in twin pregnancy, 380 mIU/ml next in ectopic pregnancy and 244.50±168.77 mIU/ml and 95.00 mIU/ml in normal singleton pregnancy and spontaneous abortion repectively. 6. Initial diagnosis of pregnancy could be obtained on the 8th to 12th day after ovulation in 83% of the cases and on the 14th day in 100% of the cases. 7. Exponential rates on β-HCG in normal singleton pregnancy were 0.271±0.051 on the 12th to 14th day after ovulation, 0.248±0.088 on the 14th to 16th day and 0.303±0.201 on the 16th to 18th day. 8. Doubling times of β-HCG in normal singleton pregnancy were 1.154±0.227 days on 12th to 14th day after ovulation, 1.511±0.853 days on 14th to 16th day and 1.092±0.280 days on 16th to 18th day.
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